Description
Product Characteristics:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Subcellular location: Secreted, Extracellular matrix
Synonyms: CCN 2, CCN-2, CCN2, Connective Tissue Growth Factor, CTGF, Hcs 24, Hcs24, Hypertrophic chondrocyte specific protein 24, Hypertrophic chondrocyte-specific gene product 24, Insulin-like Growth Factor-Binding Protein 8, MGC102839, NOV 2, NOV2, Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP8, IGFBP-8, connective tissue growth factor precursor, CTGF_HUMAN.
Target Information: The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]